Paroxetine - Wikipedia
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Swallow the extended-release tablet click and do not crush, chew, hcl break it. Tell your doctor about the allergy and what signs you side. Signs of bleeding like throwing up or coughing up blood ; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding ; bruises without a cause or that get bigger; paroxetine bleeding you cannot stop.
Do not effects taking this medicine paroxetine tablets all of a sudden without calling your doctor.
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- What is paroxetine?
All people who take this medicine paroxetine tablets need to be watched closely. Call the doctor right away if signs like low mood depression , nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse.
Call the doctor right away if any thoughts or actions of suicide occur. This medicine is not approved for use in children. Talk with the doctor. Uses of Paroxetine Tablets: It is used to treat low mood depression.
It is used to treat obsessive-compulsive problems. It is used to treat panic attacks. It is used to treat anxiety. It is used to treat post-traumatic stress. It may be given to you for other reasons. If you have an allergy to paroxetine or any other part of this medicine paroxetine tablets. If you are allergic to this medicine paroxetine tablets ; any part of this medicine paroxetine tablets ; or any other drugs, foods, or substances.
Tell your doctor about the allergy and what signs you had. If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid , phenelzine , tranylcypromine , selegiline , or rasagiline.
Very high blood pressure may happen. This is not a list of all drugs or health problems that interact with this medicine paroxetine tablets. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. You must check to make sure that it is safe for you to take this medicine paroxetine tablets with all of your drugs and health problems.
Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Paroxetine Tablets? Tell all of your health care providers that you take this medicine paroxetine tablets. This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine paroxetine tablets affects you. Do not stop taking this medicine paroxetine tablets all of a sudden without calling your doctor.
You may have a greater risk of side effects. If you need to stop this medicine paroxetine tablets , you will want to slowly stop it as ordered by your doctor. Avoid drinking alcohol while taking this medicine paroxetine tablets.
Talk with your doctor before you use other drugs and natural products that slow your actions. It may take several weeks to see the full effects. This medicine may raise the chance of a broken bone. This medicine may raise the chance of bleeding. Sometimes, bleeding can be life-threatening. Some people may have a higher chance of eye problems with this medicine paroxetine tablets.
Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain , change in eyesight, or swelling or redness in or around the eye.
A severe and sometimes deadly problem called serotonin syndrome may happen. Depression[ edit ] A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression.
They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent or inferior to other antidepressants. Credit: Dr. Central and peripheral 5-HT3 receptor stimulation is believed to result in the gastrointestinal effects observed with SSRI treatment. Unless the benefits of paroxetine justify continuing treatment, consideration should be given to stopping or switching to another antidepressant.
Evidence has shown that paroxetine has among the highest incidence rates and severity of withdrawal syndrome of any medication of its class.
Paroxetine Capsules - FDA prescribing information, side effects and uses
Drug Interaction Studies Potential Effect of Paroxetine Capsules on Other Paroxetine Drugs Metabolized by CYP3A4 An in vivo drug interaction study involving the co-administration under effects conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine pharmacokinetics. Tablet Studies The efficacy of Paroxetine Capsules as a treatment for moderate to severe VMS associated with menopause was established in two Phase 3 studies paroxetine a dose of 7.
Reported clinical 7.5 have included respiratory distress, come here, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying.
Nursing Mothers Paroxetine is excreted in human milk. The no-effect dose for rat pup mortality was not determined. Here studies investigating the effect of tablet drugs on paroxetine side listed below: Cimetidine: Cimetidine inhibits many cytochrome P enzymes.
Pharmacokinetics Absorption, Distribution, Metabolism and Excretion Absorption Paroxetine is completely absorbed after oral dosing of the mesylate salt. Other notable signs and symptoms observed with overdoses involving paroxetine alone or paroxetine other substances include mydriasis, convulsions including status epilepticusventricular dysrhythmias including torsades de pointeshypertension, aggressive reactions, syncope, hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic dysfunction including hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic steatosisserotonin syndrome, manic reactions, myoclonus, acute renal failure, and urinary retention.
Although there was a dose-related increase travel the number of tumors in mice, hcl was no drug-related increase in the number of mice with tumors. No Paroxetine Capsules dose adjustment is considered necessary in patients with renal or hepatic impairment.
Paroxetine Capsules
Paroxetine paroxetine effects Get emergency medical help if you have signs of an allergic reaction to paroxetine hivesdifficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throatburning eyes, skin pain, red or purple skin rash with blistering and peeling.
However, an increase in rat pup deaths was seen during the first 4 days of lactation when dosing travel during the last trimester of gestation and continued throughout lactation, at a paroxetine approximately equal to the maximum recommended human dose MRHD for VMS 7. Steady-state Cmax values were approximately 5 times greater than those attained after a 7.5 dose and steady-state exposure based on AUC was about 10 times greater than AUC after clomid testosterone single tablet.
Elderly patients may have elevated paroxetine plasma concentrations compared to younger patients. Commonly reported adverse reactions associated with paroxetine overdosage include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting, and dizziness.
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Your family or other caregivers should side be alert to changes in your mood or symptoms. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart ratemuscle stiffness, twitching, loss of coordination, nausea, vomiting, or tablet.
Generic Paxil Cost Paroxetine Prescription Online Ask your medical professional prior paroxetine taking paroxetine with a sleeping tablet, paroxetine pain medication, muscle relaxer, or medication for travel, depression, or seizures. Spontaneous cases of deliberate or accidental overdosage during paroxetine treatment have been reported; some of these cases were fatal and some of the fatalities appeared to involve paroxetine alone. Saturation of this enzyme at clinical doses appears to account for the nonlinearity of paroxetine kinetics with increasing dose and increasing duration of effects.
Serotonergic Drugs If concomitant use of Paroxetine Capsules with other hcl drugs e. Seek emergency medical attention or call the Poison Help line at Cardiac malformations are a common congenital abnormality.
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Atomoxetine: The effect of paroxetine on the pharmacokinetics of atomoxetine has been evaluated when both drugs were travel steady state. PPHN occurs in 1 — 2 per live births in the general population and is associated with substantial neonatal morbidity and mortality. Commonly reported adverse reactions associated with paroxetine overdosage include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting, and dizziness. Female rats were not affected. Pharmacokinetics Absorption, Distribution, Metabolism and Excretion Absorption Paroxetine is completely absorbed paroxetine oral dosing of the mesylate salt.
Source with glucuronic acid and sulfate predominate, and major metabolites have plus isolated and identified. Your doctor may occasionally change your dose.
However, other studies have failed to demonstrate such a risk [see Warnings and Precautions 5. Female rats were not affected. Paroxetine side paroxetine Get emergency medical help if you have signs of an allergic reaction to paroxetine hivesdifficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throatburning eyes, skin pain, red or tablet skin rash with blistering and peeling.
Drug Interaction Studies Potential Effect of Paroxetine Capsules on Other Drugs Drugs Metabolized by CYP3A4 An source vivo drug interaction study involving the co-administration under steady-state conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of 7.5 on terfenadine pharmacokinetics.
Paroxetine
Saturation of this enzyme at clinical doses appears to account for the nonlinearity of tablet kinetics with increasing dose and increasing duration of treatment. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
List item number one List 7.5 number two List item number three [Ref] Endrocrine negative effects have info of diabetic tablet mellitus, goiter, thyroiditis, hyperthyroidism, and also hypothyroidism. Specific studies investigating the effect of other drugs on paroxetine 7.5 listed below: Cimetidine: Cimetidine inhibits many cytochrome P enzymes.
Beta Blockers: In a study in which propranolol 80 mg twice daily was dosed orally for 18 days, the steady-state plasma concentrations of propranolol paroxetine unaltered during co-administration here paroxetine 30 mg once daily for the final 10 days.
Specific studies investigating the effect of other drugs on paroxetine are listed below: Cimetidine: Cimetidine inhibits many cytochrome P enzymes.
Spontaneous cases tablet deliberate or accidental hcl during here treatment have been side some of these cases were fatal and some of the paroxetine appeared to involve paroxetine alone.
In vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least times effects potent than paroxetine as an inhibitor of the metabolism of several substrates for CYP3A4, including astemizole, triazolam, and cyclosporine.
Renal Impairment No Paroxetine Capsules dose adjustment is considered necessary in patients with renal impairment [see Clinical Pharmacology
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- What is paroxetine?
Swallow the extended-release tablet whole and do not crush, chew, or break it. Shake the oral suspension liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. It may take up to 4 weeks before your symptoms improve.
Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using paroxetine. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light.
Detailed Paroxetine dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at An overdose of paroxetine can be fatal.
What to avoid Avoid driving or hazardous activity until you know how paroxetine will affect you. Your reactions could be impaired. Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID such as aspirin , ibuprofen Advil , Motrin , naproxen Aleve , celecoxib Celebrex , diclofenac , indomethacin , meloxicam , and others.
Drinking alcohol with this medicine can cause side effects. Paroxetine side effects Get emergency medical help if you have signs of an allergic reaction to paroxetine hives , difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat , burning eyes, skin pain, red or purple skin rash with blistering and peeling. In managing overdosage, consider the possibility of multiple drug involvement.
The molecular weight is Each pink capsule contains 9. Paroxetine Capsules are not an estrogen, and its mechanism of action for the treatment of VMS is unknown. Pharmacodynamics Studies at clinically relevant doses in humans have demonstrated that paroxetine blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that paroxetine is a selective inhibitor of neuronal serotonin reuptake and has weak effects on norepinephrine and dopamine neuronal reuptake.
In vitro radioligand binding studies indicate that paroxetine has little affinity for muscarinic alpha1-, alpha2-, beta-adrenergic-, dopamine D2 -, 5-HT1-, 5-HT2-, and histamine H1 -receptors.
Pharmacokinetics Absorption, Distribution, Metabolism and Excretion Absorption Paroxetine is completely absorbed after oral dosing of the mesylate salt. Peak concentrations were reached at a median of 6 hours 3 to 8 hours range. Steady-state AUC values were about 3 times those of AUC0-inf following a single dose, indicating non-linear pharmacokinetics. Steady-state Cmax values were approximately 5 times greater than those attained after a single dose and steady-state exposure based on AUC was about 10 times greater than AUC after a single dose.
The nonlinear kinetics and excess accumulation are due to the fact that CYP2D6, an enzyme that is in part responsible for paroxetine metabolism, is readily saturable. The effects of food on the bioavailability of paroxetine were studied with paroxetine tablets at higher strength.
Paroxetine Capsules can be taken with or without food. Paroxetine does not alter the in vitro protein binding of phenytoin or warfarin. Metabolism Paroxetine is extensively metabolized after oral administration. The principal metabolites are polar and conjugated products of oxidation and methylation, which are readily cleared.
Conjugates with glucuronic acid and sulfate predominate, and major metabolites have been isolated and identified.
The metabolism of paroxetine is accomplished in part by cytochrome CYP2D6. Saturation of this enzyme at clinical doses appears to account for the nonlinearity of paroxetine kinetics with increasing dose and increasing duration of treatment. The role of this enzyme in paroxetine metabolism also suggests potential drug-drug interactions [see Drug Interactions 7 ]. At steady state, when the CYP2D6 pathway is essentially saturated, paroxetine clearance is governed by alternative P isozymes, which, unlike CYP2D6, show no evidence of saturation.
Specific Populations Renal and Liver Impairment Increased plasma concentrations of paroxetine occur in subjects with renal and hepatic impairment.
No Paroxetine Capsules dose adjustment is considered necessary in patients with renal or hepatic impairment. No Paroxetine Capsules dose adjustment is considered necessary in elderly patients. Drug Interaction Studies Potential Effect of Paroxetine Capsules on Other Drugs Drugs Metabolized by CYP3A4 An in vivo drug interaction study involving the co-administration under steady-state conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine pharmacokinetics.
In vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least times more potent than paroxetine as an inhibitor of the metabolism of several substrates for CYP3A4, including astemizole, triazolam, and cyclosporine.
Like other agents that are metabolized by CYP2D6, paroxetine may significantly inhibit the activity of this isozyme.
Specific studies investigating the effect of paroxetine on drugs metabolized by CYP2D6 are listed below: Pimozide: Higher doses of paroxetine have been shown to elevate plasma levels of pimozide. Tamoxifen: It is uncertain whether the co-administration of paroxetine and tamoxifen has a significant adverse effect on the efficacy of tamoxifen.
However, other studies have failed to demonstrate such a risk [see Warnings and Precautions 5. Atomoxetine: The effect of paroxetine on the pharmacokinetics of atomoxetine has been evaluated when both drugs were at steady state. In healthy volunteers who were extensive metabolizers of CYP2D6, paroxetine 20 mg daily was given in combination with 20 mg atomoxetine every 12 hours.
This resulted in increases in steady-state atomoxetine AUC values that were 6- to 8-fold greater and in atomoxetine Cmax values that were 3- to 4-fold greater than when atomoxetine was given alone [see Drug Interactions 7. Beta Blockers: In a study in which propranolol 80 mg twice daily was dosed orally for 18 days, the steady-state plasma concentrations of propranolol were unaltered during co-administration with paroxetine 30 mg once daily for the final 10 days.
The effects of propranolol on paroxetine have not been evaluated. Specific studies investigating the effect of other drugs on paroxetine are listed below: Cimetidine: Cimetidine inhibits many cytochrome P enzymes. Phenobarbital: Phenobarbital induces many cytochrome P enzymes. The effect of paroxetine on phenobarbital pharmacokinetics was not studied.
Because paroxetine exhibits nonlinear pharmacokinetics, the results of this study may not address the case where the 2 drugs are both being chronically dosed [see Drug Interactions 7. Because both drugs exhibit nonlinear pharmacokinetics, the above studies may not address the case where the 2 drugs are both being chronically dosed [see Drug Interactions 7. Digoxin: A clinical drug interaction study showed that concurrent use of digoxin did not affect paroxetine exposure.
Diazepam: A clinical drug interaction study showed that concurrent use of diazepam did not affect paroxetine exposure. Female rats were not affected. Although there was a dose-related increase in the number of tumors in mice, there was no drug-related increase in the number of mice with tumors.
The relevance of these findings to humans is unknown. Mutagenesis Paroxetine produced no genotoxic effect in a battery of 5 in vitro and 2 in vivo assays that included the following: bacterial mutation assay, mouse lymphoma mutation assay, unscheduled DNA synthesis assay, and tests for cytogenetic aberrations in vivo in mouse bone marrow and in vitro in human lymphocytes and in a dominant lethal test in rats.
Irreversible lesions occurred in the reproductive tract of male rats after dosing in toxicity studies for 2 to 52 weeks. Clinical Studies The efficacy of Paroxetine Capsules as a treatment for moderate to severe VMS associated with menopause was established in two Phase 3 studies at a dose of 7.
The co-primary efficacy endpoints for both studies were the reduction from baseline in VMS frequency and severity at Weeks 4 and Data from Study 1 showed a statistically significant reduction from baseline in the frequency of moderate to severe vasomotor symptoms at Week 4 and Week 12 and a statistically significant reduction in the severity of moderate to severe VMS at Week 4 for Paroxetine Capsules compared to placebo Table 4.
Paroxetine Side Effects: Common, Severe, Long Term - killearnontheweb.co.uk
Dog Anxiety Treatment with Paroxetine
You should be closely monitored by your doctor for emotional and behaviour changes while taking this medication. Nevertheless, Prozac is more stimulating than Paxil.
Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any time point. However, you may have a relapse of depression if you stop taking your antidepressant. However, https://killearnontheweb.co.uk/wp-content/ngg/modules/photocrati-show/10133.html are not identical medications and have different FDA approval for how they are used.
Paroxetine
Comparative efficacy of paroxetine is equivalent to that of clomipramine and effects. If you have liver problems, discuss with your doctor how this medication may affect your go to the article condition, how your medical condition may affect the dosing and effectiveness tablet this medication, and whether any special monitoring is tablet.
This side effect can occur in individuals with no history of mania but it may be more likely to occur in those with bipolar or with a family history of mania. However, additional studies are necessary to confirm these findings. Report any new or 7.5 symptoms to your doctor, such as: mood or paroxetine changes, anxiety, panic attackstrouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physicallymore depressed, or have thoughts about side or hurting yourself.
Do not start paroxetine stop taking this medicine without your doctor's advice. The FDA conducted a statistical analysis of paroxetine clinical trials in children and adolescents infinding an increase in "suicidality" and ideation as compared to placebo; the trend for increased "suicidality" was observed in both trials for depression and for anxiety disorders.
Signs and hcl associated with serotonin syndrome or neuroleptic malignant syndrome included agitation, confusion, diaphoresis, diarrhea, fever, hypertension, rigidity, and tachycardiaand were in some cases associated with concomitant use of serotonergic drugs.
However, you may have a relapse of depression if you stop taking your antidepressant. Detailed Paroxetine dosage information What happens if I miss a dose? This neurotransmitter is affecting the way brain cells communicate, so serotonin levels need to be increased in order to treat dog anxiety.
Paroxetine Side Effects
Follow all directions on your prescription label and read all medication guides or instruction sheets. Store at room temperature away from moisture, heat, and light. However, you may have a relapse of depression if you stop taking your antidepressant.
If you feel that your symptoms are getting worse or you are noticing new symptoms, make an appointment with your paroxetine as soon as possible. Plasma paroxetine concentrations are generally in a range of ? Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapy, but particularly with concomitant use of other serotonergic paroxetine and drugs that impair the metabolism of serotonin.
Plasma, serum tablet blood concentrations of paroxetine may be measured to 7.5 therapeutic administration, confirm a diagnosis of 7.5 in hospitalized patients or to tablet in the medicolegal investigation of fatalities.
Your doctor or mental health practitioner is there to discuss your concerns, help you find ways of coping you may have not considered before, page a form of psychotherapy, and if needed, see if you can benefit from medication. It elevates serotonin levels in the brain, fact that leads to feelings of well-being.
This is especially true if read the article are severely affecting your ability to function in your daily tasks and interact with other people. Pharmaceutical Mechanism of Paroxetine The way Paroxetine works is rather simple.
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User Reviews for Paroxetine. Also known as: Paxil, Paxil CR, Brisdelle, Pexeva Paroxetine has an average rating of out of 10 from a total of 1, ratings on killearnontheweb.co.uk 62% of those users who reviewed Paroxetine reported a positive effect, while 19% reported a negative effect.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using paroxetine. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Detailed Paroxetine dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at An overdose of paroxetine can be fatal. What to avoid Avoid driving or hazardous activity until you know how paroxetine will affect you.
Pharmaceutical Mechanism of Paroxetine The way Paroxetine works is rather simple. It elevates serotonin levels in the brain, fact that leads to feelings of well-being. This neurotransmitter is affecting the way brain cells communicate, so serotonin levels need to be increased in order to treat dog anxiety.
Paroxetine is often compared to Prozac, which another popular drug that modifies serotonin levels. Availability and Dosage Paroxetine comes in tablets with a concentration of 20 mg or 30 mg. Since this is a prescription drug, the recommended dosage can only be determined by the veterinarian, after noticing the number and the severity of the symptoms.
Serotonin syndrome: Severe reactions are possible when paroxetine is combined with other medications that act on serotonin, such as tricyclic antidepressants, "triptan" medications for migraine and some medications to treat nausea due to chemotherapy. These combinations should be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation.
Coma and death are possible. If you are taking other medications that affect serotonin, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Stopping the medication: Stopping this medication suddenly may lead to side effects such as dizziness, abnormal dreams, numbness or tingling sensations, agitation, anxiety, nausea, vomiting, sweating, or other symptoms.
If you are thinking of stopping the medication, check with your doctor first. Your doctor may want you to decrease the dose of the medication gradually when it is time to stop taking paroxetine. Suicidal or agitated behaviour: People taking this medication may feel agitated restless, anxious, aggressive, emotional, and feeling not like themselves , or they may want to hurt themselves or others. These behavioural changes may be more likely to occur in children and adolescents, however they are possible for all age groups that use this medication.
These symptoms may occur within several weeks after starting this medication. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking this medication. Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Paroxetine has been reported to cause an increase in birth defects, primarily of the heart, in babies born to women who have taken it in the first trimester.
It has also been reported that babies born to women who took medications of this kind during the last trimester of their pregnancy may experience adverse effects such as breathing problems, seizures, trouble feeding, vomiting, low blood sugar, shaking, jitteriness, irritability, and constant crying that result in an increase in the length of hospital stay.